Article
Resolution of hypervariable regions in T-cell receptor beta chains by a modified Wu-Kabat index of amino acid diversity.
Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990
Jores R, Alzari P M, Meo T
Abstract excerpt
The Wu-Kabat variability coefficient is a well-established descriptor of the susceptibility of an amino acid position to evolutionary replacements. It conveniently highlights stretches of accentuated amino acid variation that, for example, in an antibody molecule account for most of the antigen c...
Topics
- Amino Acid Sequence
- Genes, Immunoglobulin
- Genetic Variation
- Immunoglobulin Fab Fragments
- Immunoglobulin Variable Region
- Macromolecular Substances
- Models, Molecular
- Multigene Family
- Protein Conformation
- Receptors, Antigen, T-Cell