Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of ethylnitrosourea-induced schwannoma development involves elimination of neu/erbB-2 mutant premalignant cells in the resistant BDIV rat strain.

Cancer research - 1 Sept 2000

Kindler-Röhrborn A, Kind A B, Koelsch B U, Fischer C, Rajewsky M F

Abstract excerpt

Contrary to the response of rats of the highly sensitive inbred strain BDIX, BDIV rats are resistant to the induction of malignant schwannomas by exposure to the alkylating N-nitroso carcinogen N-ethyl-N-nitrosourea (EtNU). In BDIX rats, a point mutation at nucleotide 2012 in the transmembrane region of the neu/erbB-2 gene has proved to be a very early marker of initiated Schwann precursor cells with an elevated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens
Share to Crosses, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethylnitrosourea

Share to Genes, erbB-2

Share to Neurilemmoma

Share to Point Mutation

Share to Precancerous Conditions

Share to Rats, Inbred Strains

Source

Identifiers

PMID: 10987282

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of ethylnitrosourea-induced schwannoma development involves elimination of neu/erbB-2 mutant premalignant cells in the resistant BDIV rat strain.PMID 10987282Read ↗

Early mutation of the neu (erbB-2) gene during ethylnitrosourea-induced oncogenesis in the rat Schwann cell lineage.Semantic proximity Read ↗

Gender-specific polygenic control of ethylnitrosourea-induced oncogenesis in the rat peripheral nervous system.Semantic proximity Read ↗

Genetic basis of sex-specific resistance to neuro-oncogenesis in (BDIX x BDIV) F(2) rats.Semantic proximity Read ↗

Ethylnitrosourea-induced development of malignant schwannomas in the rat: two distinct loci on chromosome of 10 involved in tumor susceptibility and oncogenesis.Semantic proximity Read ↗

Wild type neu transgene counteracts mutant homologue in malignant transformation of rat Schwann cells.Semantic proximity Read ↗

Loss of heterozygosity in malignant rat schwannomas chemically induced in hybrids of inbred rat strains with differential tumor susceptibility.Semantic proximity Read ↗

Genetic dissection of the Mss4 locus mediating sex-biased cancer resistance in the rat peripheral nervous system.Semantic proximity Read ↗

neu mutations and loss of normal allele in schwannomas induced by N-ethyl-N-nitrosourea in rats.Semantic proximity Read ↗

Infrequent transforming mutations in the transmembrane domain of the neu oncogene in spontaneous rat schwannomas.Semantic proximity Read ↗

Braf Mutations Initiate the Development of Rat Gliomas Induced by Postnatal Exposure to N-Ethyl-N-Nitrosourea.Semantic proximity Read ↗

neu proto-oncogene mutation is specific for the neurofibromas in a N-nitroso-N-ethylurea-induced hamster neurofibromatosis model but not for hamster melanomas and human Schwann cell tumors.Semantic proximity Read ↗

Overexpression of activated neu/erbB2 initiates immortalization and malignant transformation of immature Schwann cells in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.