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Article

Mutation of the human neu protein facilitates down-modulation by monoclonal antibodies.

Oncogene - 1 Apr 1990

van Leeuwen F, van de Vijver M J, Lomans J, van Deemter L, Jenster G, Akiyama T, Yamamoto T, Nusse R

Abstract excerpt

Amplification and overexpression of the neu gene have been found in several human adenocarcinomas. We have obtained monoclonal antibodies to the human neu protein by immunizing a Balb/c mouse with a Balb/c cell line expressing the human neu gene by transfection. The monoclonal antibodies reacted with neu protein on intact cells by immunofluorescence and immunoprecipitated neu in metabolically labeled cells, also...

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Source

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PMID: 1970152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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