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Article

Evidence for primary genetic determination of heart rate regulation: chromosomal mapping of a genetic locus in the rat.

Circulation - 19 Aug 1997

Kreutz R, Struk B, Stock P, Hübner N, Ganten D, Lindpaintner K

Abstract excerpt

BACKGROUND: We investigated whether an accelerated heart rate (HR), observed in the stroke-prone spontaneously hypertensive rat (SHRSP(HD)), is a primary, genetically determined trait and whether it contributes to blood pressure (BP) regulation in this model of polygenic hypertension. METHODS AND RESULTS: We measured BP and HR in SHRSP(HD) and normotensive Wistar-Kyoto rats (WKY), as well as in F2 hybrids bred...

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Identifiers

PMID: 9286932
DOI: 10.1161/01.cir.96.4.1078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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