Article
Analysis of the role of angiotensinogen in spontaneous hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Jun 1995
Lodwick D, Kaiser M A, Harris J, Cumin F, Vincent M, Samani N J
Abstract excerpt
Allelic variants at the human angiotensinogen locus have recently been reported to increase susceptibility to the development of essential hypertension. In this study we analyzed the role played by angiotensinogen in the elevated blood pressure of the spontaneously hypertensive rat (SHR). The SHR angiotensinogen locus (on chromosome 19) cosegregated with a significant (P = .003) and specific increase in pulse...
Topics
- Angiotensinogen
- Animals
- Base Sequence
- Chromosome Mapping
- Female
- Genotype
- Hypertension
- Male
- Molecular Sequence Data
- Polymorphism, Restriction Fragment Length
- RNA, Messenger