Article
Rearrangements at the 11p15 locus and overexpression of insulin-like growth factor-II gene in sporadic adrenocortical tumors.
The Journal of clinical endocrinology and metabolism - 1 Jun 1994
Gicquel C, Bertagna X, Schneid H, Francillard-Leblond M, Luton J P, Girard F, Le Bouc Y
Abstract excerpt
Little is known about the pathophysiology of sporadic adrenocortical tumors in adults. Because loss of heterozygosity at the 11p15 locus has been described in childhood tumors, particularly, in adrenocortical tumors, associated with the Beckwith-Wiedemann syndrome and because insulin-like growth factor-II (IGF-II) is a crucial regulator of fetal adrenal growth, we looked for structural analysis at the 11p15 locus...
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