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Article

Copy number variations alter methylation and parallel IGF2 overexpression in adrenal tumors.

Endocrine-related cancer - 1 Dec 2015

Nielsen Helene Myrtue, How-Kit Alexandre, Guerin Carole, Castinetti Frederic, Vollan Hans Kristian Moen, De Micco Catherine, Daunay Antoine, Taieb David, Van Loo Peter, Besse Celine, Kristensen Vessela N, Hansen Lise Lotte, Barlier Anne, Sebag Frederic, Tost Jörg

Abstract excerpt

Overexpression of insulin growth factor 2 (IGF2) is a hallmark of adrenocortical carcinomas and pheochromocytomas. Previous studies investigating the IGF2/H19 locus have mainly focused on a single molecular level such as genomic alterations or altered DNA methylation levels and the causal changes underlying IGF2 overexpression are still not fully established. In the current study, we analyzed 62 tumors of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26400872
DOI: 10.1530/ERC-15-0086
PMCID: PMC4621769

Genes

IGF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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