Two distinct tumor suppressor loci within chromosome 11p15 implicated in breast cancer progression and metastasis.

doi:10.1093/hmg/7.5.895

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Article

Two distinct tumor suppressor loci within chromosome 11p15 implicated in breast cancer progression and metastasis.

Human molecular genetics - 1 May 1998

Karnik P, Paris M, Williams B R, Casey G, Crowe J, Chen P

Abstract excerpt

Chromosome 11p15 has attracted considerable attention because of the biological importance of this region to human disease. Apart from being an important tumor suppressor locus showing loss of heterozygosity (LOH) in several adult and childhood cancers, 11p15 has been shown by linkage analysis to...

Topics

Breast
Breast Neoplasms
Carcinoma
Chromosome Mapping
Chromosomes, Human, Pair 11
Disease Progression
Female
Genes, Tumor Suppressor
Genetic Markers
Genotype
Humans
Loss of Heterozygosity
Rhabdomyosarcoma

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