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Insulin-like growth factor system on adrenocortical tumorigenesis

17 Oct 2011

Abstract excerpt

The insulin-like growth factor (IGF) signaling pathway has many important roles in normal cell growth and development. Remarkably, all of the components of this system (IGFs, receptors, and binding proteins) are expressed in human fetal adrenals. Beckwith-Wiedemann syndrome, a congenital overgrowth disorder characterized by a high risk of development of childhood tumors, is also distinguished by a high incidence...

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PMID: 22019903
DOI: 10.1016/j.mce.2011.09.042

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