Article
Pathogenesis of adrenocortical incidentalomas and genetic syndromes associated with adrenocortical neoplasms.
Endocrinology and metabolism clinics of North America - 1 Mar 2000
Gicquel C, Bertherat J, Le Bouc Y, Bertagna X
Abstract excerpt
The study of genetic syndromes associated with adrenocortical tumors (Beckwith-Wiedemann, Li-Fraumeni, McCune-Albright, Carney, and multiple endocrine neoplasia type 1) has shed light on the molecular basis of tumorigenesis. Abnormalities at the 11p15 locus appear as crucial and frequent events found specifically in malignant, sporadic tumors, leading to overexpression of a growth-promoting factor and loss of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.