Article
Intestinal differentiation and p53 gene alterations in Barrett's esophagus and esophageal adenocarcinoma.
International journal of cancer - 15 Feb 1994
Moore J H, Lesser E J, Erdody D H, Natale R B, Orringer M B, Beer D G
Abstract excerpt
The development of esophageal adenocarcinoma is frequently associated with intestinal-type Barrett's metaplasia. Barrett's metaplasia and esophageal adenocarcinomas were examined for expression of the intestinal brush-border-associated hydrolase aminopeptidase N (APN). APN mRNA was detected by utilizing the reverse transcription polymerase chain reaction (RT-PCR) in 50% of Barrett's metaplasia specimens and in...
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