Article
Mutations of p53 in Barrett's esophagus and Barrett's cancer: a prospective study of ninety-eight cases.
The Journal of thoracic and cardiovascular surgery - 1 Feb 1996
Schneider P M, Casson A G, Levin B, Garewal H S, Hoelscher A H, Becker K, Dittler H J, Cleary K R, Troster M, Siewert J R, Roth J A
Abstract excerpt
We had previously identified p53 mutations in Barrett's esophagus and therefore began a multiinstitutional study to determine their significance as a marker for malignancy. Ninety-eight patients from four institutions were studied. Forty-eight patients (37 men and 11 women, mean age 56.2 years) h...
Topics
- Adenocarcinoma
- Aged
- Barrett Esophagus
- Base Sequence
- Esophageal Neoplasms
- Female
- Genes, p53
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational