Article
Multidrug resistance in rat colon carcinoma cell lines CC531, CC531mdr+ and CC531rev.
Japanese journal of cancer research : Gann - 1 Nov 1993
Gheuens E, van der Heyden S, Elst H, Eggermont A, Van Oosterom A, De Bruijn E
Abstract excerpt
A rat colon carcinoma cell line, CC531, was exposed to stepwise increasing concentrations of colchicine. A cell line, CC531mdr+, which grows in the presence of 0.2 microM of colchicine was obtained. A revertant cell line, CC531rev was isolated upon colchicine withdrawal. The CC531mdr+ displayed a...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antibodies, Monoclonal
- Carrier Proteins
- Cell Division
- DNA, Neoplasm
- Daunorubicin
- Drug Resistance
- Membrane Glycoproteins
- Phenotype
- Rats
- Tumor Cells, Cultured