Article
Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression.
Journal of cell science - 1 Mar 1991
Shen D W, Lu Y G, Chin K V, Pastan I, Gottesman M M
Abstract excerpt
Multidrug resistance of human cancer cells may result from expression of P-glycoprotein, the product of the MRD1 gene, acting as an energy-dependent drug efflux pump. However, direct evidence that expression of the MDR1 gene contributes to the multidrug resistance of human liver carcinomas has no...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Antineoplastic Agents
- Biological Transport, Active
- Blotting, Northern
- Blotting, Southern
- Carcinoma, Hepatocellular
- Cloning, Molecular
- Drug Resistance
- Drug Screening Assays, Antitumor
- Gene Expression
- Humans
- KB Cells
- Liver Neoplasms
- Membrane Glycoproteins
- Phenotype
- Precipitin Tests
- Tumor Cells, Cultured
- Verapamil