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Article

Human hepatocellular carcinoma cell lines exhibit multidrug resistance unrelated to MRD1 gene expression.

Journal of cell science - 1 Mar 1991

Shen D W, Lu Y G, Chin K V, Pastan I, Gottesman M M

Abstract excerpt

Multidrug resistance of human cancer cells may result from expression of P-glycoprotein, the product of the MRD1 gene, acting as an energy-dependent drug efflux pump. However, direct evidence that expression of the MDR1 gene contributes to the multidrug resistance of human liver carcinomas has not been established. In this study, we tested five cell lines derived from human hepatocellular carcinomas for...

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PMID: 1676033
DOI: 10.1242/jcs.98.3.317

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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