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Article

Multifactorial resistance in LS174T human colon carcinoma cells selected with doxorubicin.

International journal of cancer - 21 Oct 1991

Rabier M J, Bruno N A, Slate D L

Abstract excerpt

A series of doxorubicin-resistant variants of the human LS174T colon carcinoma cell line was generated by stepwise selection. These variants also exhibited increased resistance to vinblastine, etoposide, cis-platinum, and melphalan, suggesting that resistance was multifactorial. The parental LS174T cell line and 3 resistant variants were examined for over-expression of P-glycoprotein, changes in total cellular...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antineoplastic Agents
Buthionine Sulfoximine
Cell Division
Cell Line
Colonic Neoplasms
Doxorubicin
Drug Resistance
Flow Cytometry
Genetic Variation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Glycoproteins

Methionine Sulfoximine

Neoplasm Proteins

Source

Identifiers

PMID: 1680816
DOI: 10.1002/ijc.2910490423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1680816-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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