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Article

Multifactorial resistance in LS174T human colon carcinoma cells selected with doxorubicin.

International journal of cancer - 21 Oct 1991

Rabier M J, Bruno N A, Slate D L

Abstract excerpt

A series of doxorubicin-resistant variants of the human LS174T colon carcinoma cell line was generated by stepwise selection. These variants also exhibited increased resistance to vinblastine, etoposide, cis-platinum, and melphalan, suggesting that resistance was multifactorial. The parental LS174T cell line and 3 resistant variants were examined for over-expression of P-glycoprotein, changes in total cellular...

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Identifiers

PMID: 1680816
DOI: 10.1002/ijc.2910490423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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