Article
Novobiocin modulates colchicine sensitivity in parental and multidrug-resistant B16 melanoma cells.
Journal of cancer research and clinical oncology - 1 Jan 1994
Nordenberg J, Kornfeld J, Wasserman L, Shafran M, Halabe E, Beery E, Landau O, Novogrodsky A, Sidi Y
Abstract excerpt
The effect of the antibiotic agent novobiocin on the sensitivity of melanoma cells to colchicine and vinblastine was examined in drug-sensitive and drug-resistant B16 melanoma cells. A cell line COL/R was selected for colchicine resistance. The COL/R cell line (resistant to 80 ng/ml colchicine) was found to possess the multidrug-resistant (MDR) phenotype. The cells were shown to be cross-resistant to vinblastine...
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