Article
Novobiocin modulates colchicine sensitivity in parental and multidrug-resistant B16 melanoma cells.
Journal of cancer research and clinical oncology - 1 Jan 1994
Nordenberg J, Kornfeld J, Wasserman L, Shafran M, Halabe E, Beery E, Landau O, Novogrodsky A, Sidi Y
Abstract excerpt
The effect of the antibiotic agent novobiocin on the sensitivity of melanoma cells to colchicine and vinblastine was examined in drug-sensitive and drug-resistant B16 melanoma cells. A cell line COL/R was selected for colchicine resistance. The COL/R cell line (resistant to 80 ng/ml colchicine) w...
Topics
- Animals
- Antimetabolites, Antineoplastic
- Cell Division
- Cell Line
- Clone Cells
- Colchicine
- Dose-Response Relationship, Drug
- Drug Resistance, Multiple
- Melanoma, Experimental
- Mice
- Novobiocin
- Phenotype
- Rhodamine 123
- Rhodamines
- Tumor Cells, Cultured
- Verapamil
- Vinblastine