Genetic alterations at the splice junction of p53 gene in human hepatocellular carcinoma.

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Article

Genetic alterations at the splice junction of p53 gene in human hepatocellular carcinoma.

Hepatology (Baltimore, Md.) - 1 Jan 1994

Hsu H C, Huang A M, Lai P L, Chien W M, Peng S Y, Lin S W

Abstract excerpt

The tumor-suppressor gene p53 may transactivate the transcription of genes that down-regulate cellular growth-related genes and may become oncogenic as a result of the production of mutant proteins or the loss of its protein expression. This study reports that alterations of the highly conserved...

Topics

Adult
Aged
Base Sequence
Blotting, Northern
Blotting, Western
Carcinoma, Hepatocellular
Genes, p53
Humans
Introns
Liver Neoplasms
Male
Middle Aged
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
RNA Splicing
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 7903951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7903951-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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