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Article

Genetic alterations at the splice junction of p53 gene in human hepatocellular carcinoma.

Hepatology (Baltimore, Md.) - 1 Jan 1994

Hsu H C, Huang A M, Lai P L, Chien W M, Peng S Y, Lin S W

Abstract excerpt

The tumor-suppressor gene p53 may transactivate the transcription of genes that down-regulate cellular growth-related genes and may become oncogenic as a result of the production of mutant proteins or the loss of its protein expression. This study reports that alterations of the highly conserved consensus intervening sequences at the splice junctions may lead to the inactivation of the p53 gene. Analyses with the...

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PMID: 7903951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Genetic alterations at the splice junction of p53 gene in human hepatocellular carcinoma.PMID 7903951Read ↗

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