Alternatively-spliced p53 mRNA in the FAA-HTC1 rat hepatoma cell line without the splice site mutations.

doi:10.1247/csf.17.427

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Article

Alternatively-spliced p53 mRNA in the FAA-HTC1 rat hepatoma cell line without the splice site mutations.

Cell structure and function - 1 Dec 1992

Fukuda I, Ogawa K

Abstract excerpt

A novel mutation of the p53 gene has been found in a rat hepatoma cell line, FAA-HTC1. This cell line carried two kinds of abnormal p53 transcripts; one lacked the exon 8 sequence, and the other had a single base substitution G to T which resulted in a new stop codon in exon 8. In the genomic DNA, this base substitution in exon 8 was present, indicating that both transcripts were transcribed from the mutated...

Topics

Animals
Base Sequence
DNA Mutational Analysis
Exons
Genes, p53
Introns
Liver Neoplasms, Experimental
Liver Regeneration
Male
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA Splicing

RNA, Messenger

RNA, Neoplasm

Rats

Rats, Inbred F344

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 1295697
DOI: 10.1247/csf.17.427

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1295697-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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