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Article

Differential in situ hybridization for determination of mutational specific expression of the p53 gene in human hepatoma cell lines.

Pathology - 1 Apr 1995

Lin Y, Ong L K, Chan S H

Abstract excerpt

The codon 249 mutation specific expression of the p53 gene was determined in 7 human hepatocellular carcinoma (HCC) cell lines. Two 20-base oligomers complementary to bases 872-891 of human p53 cDNA with a single nucleotide difference in the third position of codon 249 were end-labelled with biotin-conjugated dATP using terminal deoxynucleotidyltransferase (TdT). The hybridized oligomer was visually detected in...

Topics

Base Sequence
Blotting, Northern
Carcinoma, Hepatocellular
Codon
Gene Expression
Genes, p53
Humans
In Situ Hybridization
Liver Neoplasms
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 7567152
DOI: 10.1080/00313029500169862

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7567152-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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