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Article

Differential in situ hybridization for determination of mutational specific expression of the p53 gene in human hepatoma cell lines.

Pathology - 1 Apr 1995

Lin Y, Ong L K, Chan S H

Abstract excerpt

The codon 249 mutation specific expression of the p53 gene was determined in 7 human hepatocellular carcinoma (HCC) cell lines. Two 20-base oligomers complementary to bases 872-891 of human p53 cDNA with a single nucleotide difference in the third position of codon 249 were end-labelled with biotin-conjugated dATP using terminal deoxynucleotidyltransferase (TdT). The hybridized oligomer was visually detected in...

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PMID: 7567152
DOI: 10.1080/00313029500169862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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