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Article

Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression.

The Journal of biological chemistry - 25 Dec 1993

Altuvia S, Stein W D, Goldenberg S, Kane S E, Pastan I, Gottesman M M

Abstract excerpt

To evaluate the role of P-glycoprotein in steroid secretion in adrenal cells, we have used gene targeting to introduce a null mutation into one allele of the mdr1b gene in mouse Y1 adrenal cells. Characterization of both the wild-type and the mutant cell lines revealed the following. 1) The expression of mdr1b is enhanced by steroid hormones, in a feedback regulatory mechanism. Inhibition of steroid biosynthesis...

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PMID: 7903303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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