Article
Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression.
The Journal of biological chemistry - 25 Dec 1993
Altuvia S, Stein W D, Goldenberg S, Kane S E, Pastan I, Gottesman M M
Abstract excerpt
To evaluate the role of P-glycoprotein in steroid secretion in adrenal cells, we have used gene targeting to introduce a null mutation into one allele of the mdr1b gene in mouse Y1 adrenal cells. Characterization of both the wild-type and the mutant cell lines revealed the following. 1) The expre...
Topics
- 8-Bromo Cyclic Adenosine Monophosphate
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adrenal Glands
- Adrenocorticotropic Hormone
- Animals
- Carrier Proteins
- Cell Line
- Daunorubicin
- Drug Resistance
- Gene Expression Regulation
- Hormones
- Membrane Glycoproteins
- Mice
- Mutation
- RNA, Messenger
- Steroids
- Vinblastine