Article
Mutations to forskolin resistance result in loss of adrenocorticotropin receptors and consequent reductions in levels of G protein alpha-subunits.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 1996
Qiu R, Tsao J, Kwan W K, Schimmer B P
Abstract excerpt
A family of mutants isolated from the Y1 mouse adrenal cell line on the basis of their resistance to the growth inhibitory effects of forskolin have an underlying mutation that affects the activity of adenylyl cyclase. As part of the mutant phenotype, adenylyl cyclase is partially resistant to ac...
Topics
- Adenylyl Cyclases
- Adrenal Cortex Neoplasms
- Adrenocorticotropic Hormone
- Animals
- Clone Cells
- Colforsin
- Drug Resistance
- Enzyme Activation
- GTP-Binding Protein alpha Subunits, Gs
- GTP-Binding Proteins
- Humans
- Mice
- Mutation
- Phenotype
- Receptors, Adrenergic, beta
- Receptors, Corticotropin
- Transcription, Genetic
- Transfection