Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Steroid Deficiency Syndromes in Mice with Targeted Disruption of Cyp11a1

1 Aug 2002

Abstract excerpt

Steroid deficiencies are diseases affecting salt levels, sugar levels, and sexual differentiation. To study steroid deficiency in more detail, we used a gene-targeting technique to insert a neo gene into the first exon to disrupt Cyp11a1, the first gene in steroid biosynthetic pathways. Cyp11a1 null mice do not synthesize steroids. They die shortly after birth, but can be rescued by steroid injection. Due to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Hormonal Regulation and Hypertension
Share to Sexual Differentiation and Disorders

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12145347
DOI: 10.1210/me.2002-0055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Steroid Deficiency Syndromes in Mice with Targeted Disruption of Cyp11a1PMID 12145347Read ↗

Mutation of mouse Cyp11a1 promoter caused tissue-specific reduction of gene expression and blunted stress response without affecting reproduction.Semantic proximity Read ↗

Targeting of GFP-Cre to the mouse Cyp11a1 locus both drives cre recombinase expression in steroidogenic cells and permits generation of Cyp11a1 knock out mice.Semantic proximity Read ↗

A Humanized and Viable Animal Model for Congenital Adrenal Hyperplasia-CYP21A2-R484Q Mutant Mouse.Semantic proximity Read ↗

Genetic Disruption of cyp21a2 Leads to Systemic Glucocorticoid Deficiency and Tissues Hyperplasia in the Teleost Fish Medaka (Oryzias latipes).Semantic proximity Read ↗

Hidden disease susceptibility and sexual dimorphism in the heterozygous knockout of Cyp51 from cholesterol synthesis.Semantic proximity Read ↗

Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasiaSemantic proximity Read ↗

Phenotypic analysis of mice bearing targeted deletions of 11beta-hydroxysteroid dehydrogenases 1 and 2 genes.Semantic proximity Read ↗

Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse.Semantic proximity Read ↗

Deleting the mouse Hsd17b1 gene results in a hypomorphic Naglu allele and a phenotype mimicking a lysosomal storage disease.Semantic proximity Read ↗

Maternal sterol 27-hydroxylase is crucial for securing fetal developmentSemantic proximity Read ↗

AKR1D1 knockout mice develop a sex-dependent metabolic phenotype.Semantic proximity Read ↗

Steroid receptor knockout models: phenotypes and responses illustrate interactions between receptor signaling pathways in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.