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Article

Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor.

Journal of cellular physiology - 1 Apr 1995

Schimmer B P, Kwan W K, Tsao J, Qiu R

Abstract excerpt

This report examines the basis for adrenocorticotropin (ACTH) resistance in two mutant clones (Y6 and OS3) derived from the ACTH-responsive Y1 mouse adrenocortical tumor cell line. These two mutants were originally characterized by their failure to respond to ACTH with increased adenylyl cyclase activity and as a consequence were resistant to the steroidogenic effects of the hormone. We now demonstrate that ACTH...

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Identifiers

PMID: 7896893
DOI: 10.1002/jcp.1041630119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor.PMID 7896893Read ↗

ACTH-receptor deficient mutants of the Y1 mouse adrenocortical tumor cell line.Semantic proximity Read ↗

Mutations to forskolin resistance result in loss of adrenocorticotropin receptors and consequent reductions in levels of G protein alpha-subunits.Semantic proximity Read ↗

A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants.Semantic proximity Read ↗

Regulation of adenylyl cyclase activity by beta-adrenergic agonists in a desensitization-resistant mutant cell line.Semantic proximity Read ↗

The activation function of steroidogenic factor-1 is impaired in ACTH-resistant Y1 mutants.Semantic proximity Read ↗

Impaired steroidogenic factor 1 (NR5A1) activity in mutant Y1 mouse adrenocortical tumor cells.Semantic proximity Read ↗

A role for guanyl nucleotide-binding regulatory protein beta- and gamma-subunits in the expression of the adrenocorticotropin receptor.Semantic proximity Read ↗

Expression of adenylyl cyclase-4 (AC-4) in Y1 and forskolin-resistant adrenal cells.Semantic proximity Read ↗

Genetic heterogeneity of adrenocorticotropin (ACTH) resistance syndromes: identification of a novel mutation of the ACTH receptor gene in hereditary glucocorticoid deficiency.Semantic proximity Read ↗

Receptor-G-protein coupling in desensitization-resistant mutant adrenal cells.Semantic proximity Read ↗

The causal relationship between mutations in cAMP-dependent protein kinase and the loss of adrenocorticotropin-regulated adrenocortical functions.Semantic proximity Read ↗

Decreased levels of guanyl nucleotide-binding regulatory protein alpha-subunits in Y1 adrenocortical tumor cell mutants resistant to forskolin.Semantic proximity Read ↗

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