Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor.

doi:10.1002/jcp.1041630119

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Article

Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor.

Journal of cellular physiology - 1 Apr 1995

Schimmer B P, Kwan W K, Tsao J, Qiu R

Abstract excerpt

This report examines the basis for adrenocorticotropin (ACTH) resistance in two mutant clones (Y6 and OS3) derived from the ACTH-responsive Y1 mouse adrenocortical tumor cell line. These two mutants were originally characterized by their failure to respond to ACTH with increased adenylyl cyclase...

Topics

Adenylyl Cyclases
Adrenal Cortex Neoplasms
Adrenocorticotropic Hormone
Animals
Blotting, Southern
Cell Transformation, Neoplastic
Drug Resistance
Genes
Isoproterenol
Methylation
Mice
Mutation
Receptors, Adrenergic, beta
Receptors, Corticotropin
Transcription, Genetic
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 7896893
DOI: 10.1002/jcp.1041630119

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7896893-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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