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Article

A role for guanyl nucleotide-binding regulatory protein beta- and gamma-subunits in the expression of the adrenocorticotropin receptor.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 1998

Qiu R, Frigeri C, Schimmer B P

Abstract excerpt

Mutant Y1 mouse adrenocortical tumor cells, isolated on the basis of their resistance to the growth-inhibitory effects of forskolin, arise from single mutational events. These mutants present complex phenotypes in which the activity of Gbeta/gamma is impaired, ACTH receptor gene expression is markedly diminished, and ACTH-responsive adenylyl cyclase activity is lost. In this study, we have tested the hypothesis...

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PMID: 9849962
DOI: 10.1210/mend.12.12.0212

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A role for guanyl nucleotide-binding regulatory protein beta- and gamma-subunits in the expression of the adrenocorticotropin receptor.PMID 9849962Read ↗

Mutations to forskolin resistance result in loss of adrenocorticotropin receptors and consequent reductions in levels of G protein alpha-subunits.Semantic proximity Read ↗

Expression of adenylyl cyclase-4 (AC-4) in Y1 and forskolin-resistant adrenal cells.Semantic proximity Read ↗

Decreased levels of guanyl nucleotide-binding regulatory protein alpha-subunits in Y1 adrenocortical tumor cell mutants resistant to forskolin.Semantic proximity Read ↗

Impaired steroidogenic factor 1 (NR5A1) activity in mutant Y1 mouse adrenocortical tumor cells.Semantic proximity Read ↗

ACTH-receptor deficient mutants of the Y1 mouse adrenocortical tumor cell line.Semantic proximity Read ↗

Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor.Semantic proximity Read ↗

The activation function of steroidogenic factor-1 is impaired in ACTH-resistant Y1 mutants.Semantic proximity Read ↗

Global profiles of gene expression induced by adrenocorticotropin in Y1 mouse adrenal cells.Semantic proximity Read ↗

Regulation of adenylyl cyclase activity by beta-adrenergic agonists in a desensitization-resistant mutant cell line.Semantic proximity Read ↗

Statin-induced blockade of prenylation alters nucleocytoplasmic shuttling of GTP-binding proteins gamma2 and beta2 and enhances their suppressive effect on glucocorticoid receptor transcriptional activity.Semantic proximity Read ↗

Targeted disruption of the mouse mdr1b gene reveals that steroid hormones enhance mdr gene expression.Semantic proximity Read ↗

Transcriptional effects in GH3 cells of Gs alpha mutants associated with human pituitary tumors: stimulation of adenosine 3',5'-monophosphate response element-binding protein-mediated transcription and of prolactin and growth hormone promoter activity via protein kinase A.Semantic proximity Read ↗

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