Article
A role for guanyl nucleotide-binding regulatory protein beta- and gamma-subunits in the expression of the adrenocorticotropin receptor.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 1998
Qiu R, Frigeri C, Schimmer B P
Abstract excerpt
Mutant Y1 mouse adrenocortical tumor cells, isolated on the basis of their resistance to the growth-inhibitory effects of forskolin, arise from single mutational events. These mutants present complex phenotypes in which the activity of Gbeta/gamma is impaired, ACTH receptor gene expression is mar...
Topics
- Adenylyl Cyclases
- Adrenocorticotropic Hormone
- Animals
- Cattle
- Cyclic AMP
- GTP-Binding Proteins
- Gene Expression
- Genetic Vectors
- Humans
- Luciferases
- Mice
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- RNA, Messenger
- Receptors, Corticotropin
- Transfection