Reduced mRNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines.

doi:10.1002/jcp.1041520112

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Article

Reduced mRNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines.

Journal of cellular physiology - 1 Jul 1992

Chin K V, Chauhan S S, Abraham I, Sampson K E, Krolczyk A J, Wong M, Schimmer B, Pastan I, Gottesman M M

Abstract excerpt

We have previously shown that in Chinese hamster ovary (CHO) cells, a mutant cell line with a defective regulatory subunit (RI) for the cAMP-dependent protein kinase (Abraham et al: Mol. Cell. Biol., 7:3098-3106, 1987), and a transfectant cell line expressing the same mutant kinase, showed increa...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Adrenal Glands
Animals
Base Sequence
Cells, Cultured
Colchicine
Cricetinae
Cricetulus
Cyclic AMP
Cytotoxins
Female
Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Ovary

Polymerase Chain Reaction

Precipitin Tests

Source

Open in PubMed

Identifiers

PMID: 1352302
DOI: 10.1002/jcp.1041520112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1352302-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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