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Article

Reduced mRNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines.

Journal of cellular physiology - 1 Jul 1992

Chin K V, Chauhan S S, Abraham I, Sampson K E, Krolczyk A J, Wong M, Schimmer B, Pastan I, Gottesman M M

Abstract excerpt

We have previously shown that in Chinese hamster ovary (CHO) cells, a mutant cell line with a defective regulatory subunit (RI) for the cAMP-dependent protein kinase (Abraham et al: Mol. Cell. Biol., 7:3098-3106, 1987), and a transfectant cell line expressing the same mutant kinase, showed increased sensitivity to a number of drugs that are known to be substrates for the multidrug transporter (P-glycoprotein). In...

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PMID: 1352302
DOI: 10.1002/jcp.1041520112

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