Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells.

doi:10.1128/mcb.10.7.3596-3606.1990

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Article

Structural analysis of the mouse mdr1a (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant J774.2 cells.

Molecular and cellular biology - 1 Jul 1990

Hsu S I, Cohen D, Kirschner L S, Lothstein L, Hartstein M, Horwitz S B

Abstract excerpt

In multidrug-resistant mouse J774.2 cells, the differential overproduction of functionally distinct phosphoglycoprotein isoforms reflects the amplification or transcriptional activation or both of two mdr gene family members, mdr1a and mdr1b. The mdr1a gene is a complex transcriptional unit whose expression is associated with multiple transcript sizes. Independently selected multidrug-resistant J774.2 cell lines...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Amino Acid Sequence
Animals
Base Sequence
Cell Line
Cloning, Molecular
Drug Resistance
Exons
Genetic Variation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Introns

Membrane Glycoproteins

Mice

Molecular Sequence Data

Nucleic Acid Hybridization

Oligonucleotide Probes

Polymerase Chain Reaction

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 1972547
DOI: 10.1128/mcb.10.7.3596-3606.1990
PMCID: PMC360796

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1972547-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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