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Article

The activation function of steroidogenic factor-1 is impaired in ACTH-resistant Y1 mutants.

Endocrine research - 1 Nov 2000

Frigeri C, Schimmer B P

Abstract excerpt

This study explores the basis for the altered function of steroidogenic factor-1 (SF1) in a family of ACTH-resistant Y1 adrenal cell mutants. As determined in electrophoretic mobility shift assays, the DNA binding activity of SF1 was not impaired in the mutant clones. Instead, the ability of SF1 to interact with the coactivator, GRIP1 was affected as determined in a modified mammalian 2-hybrid assay. These...

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Source

Identifiers

PMID: 11196409
DOI: 10.3109/07435800009048631

Genes

GRIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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