ACTH-receptor deficient mutants of the Y1 mouse adrenocortical tumor cell line.

doi:10.3109/07435809509030430

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Article

ACTH-receptor deficient mutants of the Y1 mouse adrenocortical tumor cell line.

Endocrine research - 1 Jan 2000

Schimmer B P, Kwan W K, Tsao J, Qiu R

Abstract excerpt

Two mutant clones (Y6 and OS3) derived from the ACTH-responsive Y1 mouse adrenocortical tumor cell line fail to respond to ACTH with increased adenylyl cyclase activity and, as a consequence, are resistant to the steroidogenic effects of the hormone. As determined from Northern blot and RNase pro...

Topics

Adenylyl Cyclases
Adrenal Cortex Neoplasms
Adrenocorticotropic Hormone
Animals
Blotting, Southern
Drug Resistance
Methylation
Mice
Mutation
RNA, Messenger
Receptors, Adrenergic, beta-2
Receptors, Corticotropin
Transfection
Transformation, Genetic
Tumor Cells, Cultured

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