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Article

ACTH-receptor deficient mutants of the Y1 mouse adrenocortical tumor cell line.

Endocrine research - 1 Jan 2000

Schimmer B P, Kwan W K, Tsao J, Qiu R

Abstract excerpt

Two mutant clones (Y6 and OS3) derived from the ACTH-responsive Y1 mouse adrenocortical tumor cell line fail to respond to ACTH with increased adenylyl cyclase activity and, as a consequence, are resistant to the steroidogenic effects of the hormone. As determined from Northern blot and RNase protection assays, ACTH resistance in these mutants results from the failure to accumulate ACTH receptor transcripts. The...

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PMID: 7588376
DOI: 10.3109/07435809509030430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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ACTH-receptor deficient mutants of the Y1 mouse adrenocortical tumor cell line.PMID 7588376Read ↗

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