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Article

A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants.

Endocrinology - 1 Oct 2002

Frigeri Claudia, Tsao Jennivine, Cordova Martha, Schimmer Bernard P

Abstract excerpt

ACTH resistance in mutant derivatives of the Y1 mouse adrenocortical tumor cell line results from a defect that affects the activity of steroidogenic factor-1 (SF1), thereby preventing the expression of the melanocortin-2 receptor. In this report, we show that the SF1 genes in ACTH-resistant mutants differ from the gene in ACTH-responsive Y1 cells by two base changes-one that changes an Ala to Ser at codon 172,...

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PMID: 12239114
DOI: 10.1210/en.2002-220349

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants.PMID 12239114Read ↗

SF1 polymorphisms in the mouse and steroidogenic potential.Semantic proximity Read ↗

Impaired steroidogenic factor 1 (NR5A1) activity in mutant Y1 mouse adrenocortical tumor cells.Semantic proximity Read ↗

Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor.Semantic proximity Read ↗

ACTH-receptor deficient mutants of the Y1 mouse adrenocortical tumor cell line.Semantic proximity Read ↗

The activation function of steroidogenic factor-1 is impaired in ACTH-resistant Y1 mutants.Semantic proximity Read ↗

Mutations to forskolin resistance result in loss of adrenocorticotropin receptors and consequent reductions in levels of G protein alpha-subunits.Semantic proximity Read ↗

Adrenocorticotropin-Dependent Changes in SF-1/DAX-1 Ratio Influence Steroidogenic Genes Expression in a Novel Model of Glucocorticoid-Producing Adrenocortical Cell Lines Derived from Targeted TumorigenesisSemantic proximity Read ↗

Genetic heterogeneity of adrenocorticotropin (ACTH) resistance syndromes: identification of a novel mutation of the ACTH receptor gene in hereditary glucocorticoid deficiency.Semantic proximity Read ↗

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Global profiles of gene expression induced by adrenocorticotropin in Y1 mouse adrenal cells.Semantic proximity Read ↗

Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4.Semantic proximity Read ↗

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