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Article

A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants.

Endocrinology - 1 Oct 2002

Frigeri Claudia, Tsao Jennivine, Cordova Martha, Schimmer Bernard P

Abstract excerpt

ACTH resistance in mutant derivatives of the Y1 mouse adrenocortical tumor cell line results from a defect that affects the activity of steroidogenic factor-1 (SF1), thereby preventing the expression of the melanocortin-2 receptor. In this report, we show that the SF1 genes in ACTH-resistant mutants differ from the gene in ACTH-responsive Y1 cells by two base changes-one that changes an Ala to Ser at codon 172,...

Topics

Adrenal Cortex Neoplasms
Adrenocorticotropic Hormone
Alleles
Animals
Base Sequence
Cells, Cultured
DNA-Binding Proteins
Drug Resistance, Neoplasm
Fushi Tarazu Transcription Factors
Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homeodomain Proteins

Mice

Molecular Sequence Data

Mutation

Polymorphism, Genetic

Receptors, Cytoplasmic and Nuclear

Species Specificity

Steroidogenic Factor 1

Source

Identifiers

PMID: 12239114
DOI: 10.1210/en.2002-220349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants.PMID 12239114Read ↗

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Impaired steroidogenic factor 1 (NR5A1) activity in mutant Y1 mouse adrenocortical tumor cells.Semantic proximity Read ↗

Adrenocorticotropin-resistant mutants of the Y1 adrenal cell line fail to express the adrenocorticotropin receptor.Semantic proximity Read ↗

ACTH-receptor deficient mutants of the Y1 mouse adrenocortical tumor cell line.Semantic proximity Read ↗

The activation function of steroidogenic factor-1 is impaired in ACTH-resistant Y1 mutants.Semantic proximity Read ↗

Mutations to forskolin resistance result in loss of adrenocorticotropin receptors and consequent reductions in levels of G protein alpha-subunits.Semantic proximity Read ↗

Adrenocorticotropin-Dependent Changes in SF-1/DAX-1 Ratio Influence Steroidogenic Genes Expression in a Novel Model of Glucocorticoid-Producing Adrenocortical Cell Lines Derived from Targeted TumorigenesisSemantic proximity Read ↗

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Forskolin-resistant Y1 adrenal cell mutants are deficient in adenylyl cyclase type 4.Semantic proximity Read ↗

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