Article
Regulation of adenylyl cyclase activity by beta-adrenergic agonists in a desensitization-resistant mutant cell line.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 1991
Olson M F, Tsao J, Pon D J, Schimmer B P
Abstract excerpt
Mutant clones resistant to ACTH-induced desensitization of adenylyl cyclase (Y1DR) were previously isolated from the Y1 mouse adrenocortical tumor cell line. In this study, both parental Y1 cells (Y1DS) and a Y1DR mutant were transfected with a gene encoding the mouse beta 2-adrenergic receptor, and transfectants isolated from both Y1DS and Y1DR cells were shown to express beta 2-adrenergic receptors. These...
Topics
- Adenylyl Cyclases
- Adrenal Cortex Neoplasms
- Adrenocorticotropic Hormone
- Animals
- Gene Expression
- Iodocyanopindolol
- Isoproterenol
- Mice
- Mutation
- Pindolol
- Plasmids