Article
Expression of the multidrug resistance gene product (P-glycoprotein) in myelodysplasia is associated with a stem cell phenotype.
British journal of haematology - 1 May 1991
List A F, Spier C M, Cline A, Doll D C, Garewal H, Morgan R, Sandberg A A
Abstract excerpt
Previous studies have indicated relative resistance to chemotherapy in the myelodysplastic syndromes (MDS) and associated acute leukaemia. To determine if multidrug resistance may contribute to chemoresistance in these disorders, we studied bone marrow specimens for P-glycoprotein expression (P-G...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Acute Disease
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Monoclonal
- Bone Marrow
- Doxorubicin
- Drug Resistance
- Female
- Gene Expression
- Humans
- Leukemia, Myeloid
- Male
- Membrane Glycoproteins
- Middle Aged
- Myelodysplastic Syndromes
- Phenotype