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Article

ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription.

Molecular and cellular biology - 1 Jun 1996

Marcus G A, Horiuchi J, Silverman N, Guarente L

Abstract excerpt

In this report we described the cloning and characterization of ADA5, a gene identified by resistance to GAL4-VP16-mediated toxicity. ADA5 binds directly to the VP16 activation domain but not to a transcriptionally defective VP16 double point mutant. Double mutants with mutations in ada5 and other genes (ada2 or ada3) isolated by resistance to GAL4-VP16 grow like ada5 single mutants, suggesting that ADA5 is in...

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Source

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Identifiers

PMID: 8649430
DOI: 10.1128/MCB.16.6.3197
PMCID: PMC231313

Genes

ADA
ADA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription.PMID 8649430Read ↗

SPT20/ADA5 encodes a novel protein functionally related to the TATA-binding protein and important for transcription in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.Semantic proximity Read ↗

ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2.Semantic proximity Read ↗

Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes.Semantic proximity Read ↗

Characterization of new Spt3 and TATA-binding protein mutants of Saccharomyces cerevisiae: Spt3 TBP allele-specific interactions and bypass of Spt8.Semantic proximity Read ↗

ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.Semantic proximity Read ↗

The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4.Semantic proximity Read ↗

Differential requirement of SAGA components for recruitment of TATA-box-binding protein to promoters in vivo.Semantic proximity Read ↗

Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction.Semantic proximity Read ↗

Genetic evidence for the interaction of the yeast transcriptional co-activator proteins GCN5 and ADA2.Semantic proximity Read ↗

The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.Semantic proximity Read ↗

The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

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