Article
The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex.
The Journal of biological chemistry - 8 Mar 2002
Sterner David E, Wang Xun, Bloom Melissa H, Simon Gabriel M, Berger Shelley L
Abstract excerpt
Transcription is regulated through chromatin remodeling and histone modification, mediated by large protein complexes. Histone and nucleosome interaction has been shown to be mediated by specific chromatin domains called bromodomains and chromodomains. Here we provide evidence for a similar function of two additional domains within the yeast SAGA complex, containing the histone acetyltransferase Gcn5. We have...
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