Trypsin-resistant protease activation mutants of an influenza virus.

doi:10.1099/0022-1317-76-3-625

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Article

Trypsin-resistant protease activation mutants of an influenza virus.

The Journal of general virology - 1 Mar 1995

Orlich M, Linder D, Rott R

Abstract excerpt

New classes of mutants of influenza virus A/seal/Mass/1/80 are described in which the haemagglutinins (HA) have lost their protease cleavability by trypsin, but can be activated by elastase, chymotrypsin or thermolysin in different cell types. The same proteases that were required for activation of infectivity of the mutants also activated haemolysis and cell-fusing properties. The protease activation...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Fusion
Chick Embryo
Chickens
DNA Mutational Analysis
Endopeptidases
Enzyme Activation
Hemagglutinins, Viral
Hemolysis
Immunity, Active

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Influenza A virus

Molecular Sequence Data

Mutation

Orthomyxoviridae Infections

Seals, Earless

Sequence Analysis

Source

Open in PubMed

Identifiers

PMID: 7897352
DOI: 10.1099/0022-1317-76-3-625

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7897352-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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