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Article

Thermolysin activation mutants with changes in the fusogenic region of an influenza virus hemagglutinin.

Journal of virology - 1 Nov 1994

Orlich M, Rott R

Abstract excerpt

Influenza virus A/seal/Mass/1/80 (H7N7) mutants were obtained; the hemagglutinins (HAs) of the mutants were not activated by trypsin, as in the wild-type virus, but by thermolysin. The mutants grew efficiently under multiple replication cycle conditions and formed plaques in chicken embryo cells only when thermolysin was added to the culture medium. They exhibited hemolytic activity and induced protective...

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Identifiers

PMID: 7933138
DOI: 10.1128/JVI.68.11.7537-7539.1994
PMCID: PMC237197

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