Thermolysin activation mutants with changes in the fusogenic region of an influenza virus hemagglutinin.

Abstract excerpt

Influenza virus A/seal/Mass/1/80 (H7N7) mutants were obtained; the hemagglutinins (HAs) of the mutants were not activated by trypsin, as in the wild-type virus, but by thermolysin. The mutants grew efficiently under multiple replication cycle conditions and formed plaques in chicken embryo cells...

Topics

• Amino Acid Sequence
• Animals
• Base Sequence
• Chick Embryo
• Hemagglutinin Glycoproteins, Influenza Virus
• Hemagglutinins, Viral
• Influenza A virus
• Molecular Sequence Data
• Mutation
• Structure-Activity Relationship
• Thermolysin
• Trypsin