Article
The hemagglutinin cleavability of a virulent avian influenza virus by subtilisin-like endoproteases is influenced by the amino acid immediately downstream of the cleavage site.
Virology - 10 Jul 1995
Horimoto T, Kawaoka Y
Abstract excerpt
Many viral membrane glycoproteins are post-translationally processed by intracellular endoproteases such as subtilisin-like proteases. These proteases recognize a cleavage site sequence comprising basic amino acids positioned upstream of the cleavage site of the viral proteins. Here, we mutated t...
Topics
- Amino Acid Sequence
- Amino Acids
- Furin
- Hemagglutinins, Viral
- Influenza A virus
- Molecular Sequence Data
- Mutation
- Proprotein Convertase 5
- Protein Processing, Post-Translational
- Serine Endopeptidases
- Substrate Specificity
- Subtilisins
- Tumor Cells, Cultured
- Vaccinia virus