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Article

The potential of a protease activation mutant of a highly pathogenic avian influenza virus for a pandemic live vaccine.

Vaccine - 13 Feb 2008

Gabriel G, Garn H, Wegmann M, Renz H, Herwig A, Klenk H-D, Stech J

Abstract excerpt

The most effective countermeasure against a pandemic originating from a highly pathogenic avian influenza virus (HPAIV) is immunoprophylaxis of the human population. We present here a new approach for the development of a pandemic HPAIV live vaccine. Using reverse genetics, we replaced the polybasic hemagglutinin cleavage site of an H7N7 HPAIV with an elastase motif. This mutant was strictly elastase-dependent,...

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Source

Identifiers

PMID: 18164519
DOI: 10.1016/j.vaccine.2007.11.052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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