Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Importance of conserved amino acids at the cleavage site of the haemagglutinin of a virulent avian influenza A virus.

The Journal of general virology - 1 Feb 1993

Walker J A, Kawaoka Y

Abstract excerpt

The virulence of avian influenza A viruses depends on the cleavability of the haemagglutinin (HA) by an intracellular protease at multiple basic amino acids. Although previous studies have demonstrated the importance of these amino acids for processing by the cellular protease, with emphasis on conserved residues near the cleavage site, the minimal requirements for cleavage remain unknown. By expressing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Conserved Sequence
Share to Hemagglutinins, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Influenza A virus

Share to Molecular Sequence Data

Share to Mutation

Share to Virulence

Source

Identifiers

PMID: 8429306
DOI: 10.1099/0022-1317-74-2-311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Importance of conserved amino acids at the cleavage site of the haemagglutinin of a virulent avian influenza A virus.PMID 8429306Read ↗

The hemagglutinin cleavability of a virulent avian influenza virus by subtilisin-like endoproteases is influenced by the amino acid immediately downstream of the cleavage site.Semantic proximity Read ↗

Non-basic amino acids in the hemagglutinin proteolytic cleavage site of a European H9N2 avian influenza virus modulate virulence in turkeys.Semantic proximity Read ↗

A Single Amino Acid at the Hemagglutinin Cleavage Site Contributes to the Pathogenicity and Neurovirulence of H5N1 Influenza Virus in MiceSemantic proximity Read ↗

Acquisition of a polybasic hemagglutinin cleavage site by a low-pathogenic avian influenza virus is not sufficient for immediate transformation into a highly pathogenic strain.Semantic proximity Read ↗

Variable impact of the hemagglutinin polybasic cleavage site on virulence and pathogenesis of avian influenza H7N7 virus in chickens, turkeys and ducksSemantic proximity Read ↗

Composition of the Hemagglutinin Polybasic Proteolytic Cleavage Motif Mediates Variable Virulence of H7N7 Avian Influenza Viruses.Semantic proximity Read ↗

Structural variation occurring in the hemagglutinin of influenza virus A/turkey/Oregon/71 during adaptation to different cell types.Semantic proximity Read ↗

Insertion of a Multibasic Cleavage Motif into the Hemagglutinin of a Low-Pathogenic Avian Influenza H6N1 Virus Induces a Highly Pathogenic PhenotypeSemantic proximity Read ↗

H9 avian influenza reassortant with engineered polybasic cleavage site displays a highly pathogenic phenotype in chickenSemantic proximity Read ↗

The role of the N-terminal caspase cleavage site in the nucleoprotein of influenza A virus in vitro and in vivo.Semantic proximity Read ↗

Molecular Determinants within the Surface Proteins Involved in the Pathogenicity of H5N1 Influenza Viruses in ChickensSemantic proximity Read ↗

Highly Pathogenic H5N1 Influenza Viruses Carry Virulence Determinants beyond the Polybasic Hemagglutinin Cleavage SiteSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.