Importance of conserved amino acids at the cleavage site of the haemagglutinin of a virulent avian influenza A virus.

doi:10.1099/0022-1317-74-2-311

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Article

Importance of conserved amino acids at the cleavage site of the haemagglutinin of a virulent avian influenza A virus.

The Journal of general virology - 1 Feb 1993

Walker J A, Kawaoka Y

Abstract excerpt

The virulence of avian influenza A viruses depends on the cleavability of the haemagglutinin (HA) by an intracellular protease at multiple basic amino acids. Although previous studies have demonstrated the importance of these amino acids for processing by the cellular protease, with emphasis on c...

Topics

Amino Acid Sequence
Conserved Sequence
Hemagglutinins, Viral
Influenza A virus
Molecular Sequence Data
Mutation
Virulence

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