Article
Influenza B virus with modified hemagglutinin cleavage site as a novel attenuated live vaccine.
The Journal of infectious diseases - 15 Nov 2011
Stech Jürgen, Garn Holger, Herwig Astrid, Stech Olga, Dauber Bianca, Wolff Thorsten, Mettenleiter Thomas C, Klenk Hans-Dieter
Abstract excerpt
BACKGROUND: Both pandemic and interpandemic influenza is associated with high morbidity and mortality worldwide. Seasonal epidemics are caused by both influenza A and B virus strains that cocirculate with varying predominance and may give rise to severe illness equally. According to World Health Organization recommendations, current annual vaccines are composed of 2 type A and 1 type B virus-specific component....
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