Article
A new approach to an influenza live vaccine: modification of the cleavage site of hemagglutinin.
Nature medicine - 1 Jun 2005
Stech J, Garn H, Wegmann M, Wagner R, Klenk H-D
Abstract excerpt
A promising approach to reduce the impact of influenza is the use of an attenuated, live virus as a vaccine. Using reverse genetics, we generated a mutant of strain A/WSN/33 with a modified cleavage site within its hemagglutinin, which depends on proteolytic activation by elastase. Unlike the wild-type, which requires trypsin, this mutant is strictly dependent on elastase. Both viruses grow equally well in cell...
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