Article
New determinant of influenza hemagglutinin cleavability identified through random mutagenesis for acid-stabilizing mutations.
Microbiology spectrum - 7 Jul 2026
Rimaux S, Oliva M F, Mestdagh C, Van Berwaer R, Chen J, Schurmans L, Schoofs G, Vanmechelen B, Stroobants J, Jacquemyn M, Laporte M, Maes P, Vermeire K, Das K, Stevaert A, Naesens L
Abstract excerpt
The structural instability of influenza hemagglutinin (HA) is related to its function in low pH-mediated membrane fusion, which requires prior cleavage of the premature HA0 by a host protease. Mapping the precise determinants of HA cleavability and stability has implications for risk assessment of zoonotic influenza A viruses, viral transmissibility, and vaccine production. Here, we conducted random mutagenesis...
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