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Article

A new approach to an influenza life vaccine: haemagglutinin cleavage site mutants generated by reverse genetics.

Berliner und Munchener tierarztliche Wochenschrift - 1 Jan 2000

Stech Jürgen, Klenk Hans-Dieter

Abstract excerpt

A promising approach to reduce the impact of influenza is the use of an attenuated life virus as a vaccine. Using reverse genetics, a mutant of strain A/WSN/33 with a modified cleavage site within its haemagglutinin was generated which depends on proteolytic activation by elastase. Unlike the wild-type requiring trypsin, this mutant is strictly dependent on elastase. Both viruses grow equally well in cell culture...

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Source

Identifiers

PMID: 16573209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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