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Article

Generation of seal influenza virus variants pathogenic for chickens, because of hemagglutinin cleavage site changes.

Journal of virology - 1 Jul 1990

Li S Q, Orlich M, Rott R

Abstract excerpt

Influenza virus A/seal/Mass/1/80 (H7N7) was adapted to grow in MDCK cells and chicken embryo cells (CEC) in the absence of exogenous protease. The biological properties of the virus variants obtained coincided with intracellular activation of the hemagglutinin (HA) by posttranslational proteolyti...

Topics

Amino Acid Sequence
Animals
Base Sequence
Caniformia
Cell Line
Chick Embryo
Chickens
Dogs
Electrophoresis, Gel, Two-Dimensional
Hemagglutinins, Viral
Influenza A virus
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Peptide Hydrolases

Seals, Earless

Species Specificity

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 2191148
DOI: 10.1128/JVI.64.7.3297-3303.1990
PMCID: PMC249560

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2191148-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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