Article
Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box.
The Journal of biological chemistry - 17 Mar 1995
Ono S J, Song Z
Abstract excerpt
We have previously described a mutant B lymphoblastoid cell line, Clone-13, that expresses HLA-DQ in the absence of HLA-DR and -DP. Several criteria indicated that the defect in this cell line influences the activity of an isotype-specific transcription factor. Indeed, transient transfection of H...
Topics
- B-Lymphocytes
- Base Sequence
- Binding Sites
- Clone Cells
- DNA Primers
- Gene Expression
- Genes, MHC Class II
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DR alpha-Chains
- Humans
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation
- Promoter Regions, Genetic
- Regulatory Sequences, Nucleic Acid
- Transcription Factors