Defective HLA DRA X box binding in the class II transactive transcription factor mutant 6.1.6 and in cell lines from class II immunodeficient patients.

Abstract excerpt

6.1.6 is one of several immunoselected mutants from EBV-transformed human B cell lines that have undergone coordinate loss of expression of all their HLA class II genes. Similar defects have been found in cells from some patients with class II immunodeficiencies. Previous studies have suggested that the defects in 6.1.6 and in the other class II regulatory mutants are in transactive factors required for class II...

Topics

• Cell Line
• Chromosome Mapping
• Genes, MHC Class II
• HLA-DR Antigens
• Humans
• Immunologic Deficiency Syndromes
• Mutation
• Phenanthrolines
• Promoter Regions, Genetic
• Trans-Activators