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Article

An isotype-specific activator of major histocompatibility complex (MHC) class II genes that is independent of class II transactivator.

The Journal of experimental medicine - 2 Jun 1997

Douhan J, Lieberson R, Knoll J H, Zhou H, Glimcher L H

Abstract excerpt

Patients with one type of major histocompatibility complex class II combined immunodeficiency have mutations in a gene termed class II transactivator (CIITA), which coordinately controls the transcription of the three major human class II genes, HLA-DR, -DQ, and -DP. However, the experimentally derived B-lymphoblastoid cell line, clone 13, expresses high levels of HLADQ in the absence of HLA-DR and HLA-DP,...

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Source

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Identifiers

PMID: 9166418
DOI: 10.1084/jem.185.11.1885
PMCID: PMC2196342

Genes

CIITA

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

An isotype-specific activator of major histocompatibility complex (MHC) class II genes that is independent of class II transactivator.PMID 9166418Read ↗

An isotype-specific trans-acting factor is defective in a mutant B cell line that expresses HLA-DQ, but not -DR or -DP.Semantic proximity Read ↗

Mapping of the interaction site of the defective transcription factor in the class II major histocompatibility complex mutant cell line clone-13 to the divergent X2-box.Semantic proximity Read ↗

Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysis.Semantic proximity Read ↗

Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA.Semantic proximity Read ↗

Defective MHC class II expression in an MHC class II deficiency patient is caused by a novel deletion of a splice donor site in the MHC class II transactivator gene.Semantic proximity Read ↗

Two newly diagnosed HLA class II-deficient patients identified by rapid vector-based complementation analysis reveal discoordinate invariant chain expression levels.Semantic proximity Read ↗

Three novel mutations of the CIITA gene in MHC class II-deficient patients with a severe immunodeficiency.Semantic proximity Read ↗

MHC class II-deficient tumor cell lines with a defective expression of the class II transactivator.Semantic proximity Read ↗

Class II transactivator is required for maximal expression of HLA-DOB in B cells.Semantic proximity Read ↗

Induction of MHC class I expression by the MHC class II transactivator CIITA.Semantic proximity Read ↗

Single nucleotide polymorphisms in MHC2TA, the gene encoding the MHC class II transactivator (CIITA).Semantic proximity Read ↗

Defective class II transactivator expression in a B lymphoma cell line.Semantic proximity Read ↗

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