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Article

Class II MHC transcriptional mutants are defective in higher order complex formation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1993

Riley J L, Boss J M

Abstract excerpt

Human class II MHC genes are regulated in part by a series of conserved upstream sequence elements termed the X1, X2, and Y boxes. Class II MHC transcriptional mutant B cell lines have been defined that differ with regard to the presence of RFX, an X1 box DNA-binding activity. To further characterize these mutant cell lines, we tested the ability of these conserved upstream elements to respond to the presence of...

Topics

B-Lymphocytes
Base Sequence
Cell Line
Conserved Sequence
DNA
Gene Expression
Genes, MHC Class II
Genetic Vectors
HLA-DR Antigens
HLA-DR alpha-Chains
Humans
Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Transcription, Genetic

Transcriptional Activation

Transfection

Source

Identifiers

PMID: 8258702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8258702-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Class II MHC transcriptional mutants are defective in higher order complex formation.PMID 8258702Read ↗

Genetic complexity of regulatory mutants defective for HLA class II gene expression.Semantic proximity Read ↗

RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.Semantic proximity Read ↗

Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter.Semantic proximity Read ↗

Regulatory factor-X binding to mutant HLA-DRA promoter sequences.Semantic proximity Read ↗

A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome).Semantic proximity Read ↗

Functional complementation of major histocompatibility complex class II regulatory mutants by the purified X-box-binding protein RFX.Semantic proximity Read ↗

Analysis of the defect in IFN-gamma induction of MHC class II genes in G1B cells: identification of a novel and functionally critical leucine-rich motif (62-LYLYLQL-68) in the regulatory factor X 5 transcription factor.Semantic proximity Read ↗

Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complexSemantic proximity Read ↗

Novel mutations within the RFX-B gene and partial rescue of MHC and related genes through exogenous class II transactivator in RFX-B-deficient cells.Semantic proximity Read ↗

New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study.Semantic proximity Read ↗

The DNA-binding defect observed in major histocompatibility complex class II regulatory mutants concerns only one member of a family of complexes binding to the X boxes of class II promoters.Semantic proximity Read ↗

A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.Semantic proximity Read ↗

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