An isotype-specific trans-acting factor is defective in a mutant B cell line that expresses HLA-DQ, but not -DR or -DP.

doi:10.1084/jem.173.3.629

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Article

An isotype-specific trans-acting factor is defective in a mutant B cell line that expresses HLA-DQ, but not -DR or -DP.

The Journal of experimental medicine - 1 Mar 1991

Ono S J, Bazil V, Sugawara M, Strominger J L

Abstract excerpt

The B lymphoblastoid cell line clone 13 (a subclone of the mutant cell line P3JHR-1) has been found to express high levels of HLA-DQ; by contrast, HLA-DR and -DP antigens are not expressed and cannot be induced by interferon gamma. Northern blot analysis using gene-specific probes indicated that the lack of surface expression of the DR and DP antigens is due to a marked decrease in the levels of steady-state RNA...

Topics

Antibodies, Monoclonal
B-Lymphocytes
Base Sequence
Cell Fusion
Cell Line
Clone Cells
DNA Probes
Fluorescent Antibody Technique
HLA-DP Antigens
HLA-DQ Antigens
HLA-DR Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Mutation

Oligonucleotide Probes

Phenotype

Plasmids

RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 1997650
DOI: 10.1084/jem.173.3.629
PMCID: PMC2118821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1997650-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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