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Article

Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition.

The Journal of experimental medicine - 1 Jan 1990

Kwok W W, Mickelson E, Masewicz S, Milner E C, Hansen J, Nepom G T

Abstract excerpt

18 transfected cell lines were generated that expressed distinct DQ molecules related to the serologically defined HLA-DQw3 specificity. These transfectants were constructed using site-directed mutagenesis to introduce nucleotide substitutions into DQ3.2 beta cDNA, followed by retrovirus-mediated gene expression of the mutagenized genes in human B cell lines with different endogenous DQ alpha chains. The capacity...

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Identifiers

PMID: 2104922
DOI: 10.1084/jem.171.1.85
PMCID: PMC2187655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphic DQ alpha and DQ beta interactions dictate HLA class II determinants of allo-recognition.PMID 2104922Read ↗

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