Article
Mutational analysis of the DRA promoter: cis-acting sequences and trans-acting factors.
Molecular and cellular biology - 1 Feb 1990
Tsang S Y, Nakanishi M, Peterlin B M
Abstract excerpt
Class II major histocompatibility genes are expressed at high levels in B lymphocytes and are gamma interferon (IFN-gamma) inducible in many other cells. Previously, we observed that DRA promoter sequences from positions -150 to +31 determine the tissue specificity of this class II gene. Moreover, Z and X boxes located between positions -145 and -87 conferred B-cell specificity and IFN-gamma inducibility upon a...
Topics
- Base Sequence
- Cell Line
- Cell Nucleus
- Gene Expression
- Genes, MHC Class II
- HLA-DR Antigens
- HeLa Cells
- Humans
- Interferon-gamma
- Models, Genetic
- Molecular Sequence Data
- Mutation